Have you ever heard of glutathione (pronounced; gloota-thigh-own)? Neither has almost anyone else. Many researchers say it’s probably the most important substance we require to stay healthy. Many go as far to say it’s the secret to prevent aging. So where’s Oprah, and the rest of the media? A quick search of the term “glutathione” on PubMed.gov reveals 94,117 scholarly articles, reviews and abstracts.

Present in every cell of our body, glutathione levels just might be one of the best biochemical markers there is; the higher your glutathione levels are the healthier you will be. Glutathione deficiency is found in almost all patients with extreme illnesses, e.g., cancer, heart disease, Parkinson’s disease, Alzheimer’s, arthritis, liver disease, diabetes and more. In fact, researchers are concluding glutathione deficiency may play a role in patients with schizophrenia. In cerebrospinal fluid of drug-free schizophrenic patients, a significant decrease in the level of total glutathione was observed as compared to controls. EJN

Glutathione’s importance to a properly functioning immune system has been shown in many studies. According to Dr. Gustavo Bounous, “The limiting factor for the proper activity and multiplication of our lymphocytes (white blood cells) is the availability of glutathione”.

Every day our bodies are exposed to stress, pollution, infection, drugs (illicit or licit) and alcohol, poor diet, infections and injury, which drain our bodies of glutathione; this depletion leaves our bodies susceptible to high levels of oxidative stress, which leads to aging, disease and eventual death. I predict that concern about glutathione levels will eventually be on par with other preventative health issues.

It’s no secret, the positive anti-aging effects Human growth hormone and insulin-like growth factor-1 has on the body including increased fat metabolism, increased muscle mass, increased bone density, collagen rejuvenation, and more. Although the exact mechanisms that are most efficacious for stimulating release of these anti-aging hormones remains some-what of a mystery, scientists are getting closer.

Evidence suggests that load and frequency are determining factors in the regulation of hGH secretion. Despite the significant exercise-induced growth hormone response (EIGR) induced by resistance training, much of the stimulus for protein synthesis has been attributed to insulin-like growth factor-1 with modest contributions from the hGH-GH receptor interaction on the cell membrane. The EIGR to endurance exercise is associated with the intensity, duration, frequency and mode of endurance exercise. A number of studies have suggested an intensity ‘threshold’ exists for EIGR. An exercise intensity above lactate threshold and for a minimum of 10 minutes appears to elicit the greatest stimulus to the secretion of hGH. Exercise training above the lactate threshold may amplify the pulsatile release of hGH at rest, increasing 24-hour hGH secretion. The impact of chronic exercise training on the EIGR remains equivocal. Recent evidence suggests that endurance training results in decreased resting hGH and a blunted EIGR, which may be linked to an increased tissue sensitivity to hGH.
Sports Med. 2003;33(8):599-613.